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Emerging roles for interleukin-18 in the gastrointestinal tumor microenvironment


Fung, KY; Nguyen, PM; Putoczki, TL
2020
Advances in Experimental Medicine and Biology
Journal Article
1240
59-72
Interleukin (IL)-18, a member of the IL-1 family of cytokines, has emerged as a key regulator of mucosal homeostasis within the gastrointestinal tract. Like other members of this family, IL-18 is secreted as an inactive protein and is processed into its active form by caspase-1, although other contributors to precursor processing are emerging.Numerous studies have evaluated the role of IL-18 within the gastrointestinal tract using genetic or complementary pharmacological tools and have revealed multiple roles in tumorigenesis. Most striking among these are the divergent roles for IL-18 in colon and gastric cancers. Here, we review our current understanding of IL-18 biology and how this applies to colorectal and gastric cancers.
Springer
Personalised Oncology
10.1007/978-3-030-38315-2_5
32060888
Refer to copyright notice on published article.

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Creation Date 2020-05-04 11:46:51 Last Modified 2020-05-04 01:58:10