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Improving vaccines by targeting antigens to dendritic cells


Shortman, K; Lahoud, MH; Caminschi, I
2009-02-28
EXPERIMENTAL AND MOLECULAR MEDICINE
Journal Article
41
2
61-66
A new approach to enhancing the effectiveness of vaccines is to deliver antigens selectively to dendritic cells (DC) in situ, via monoclonal antibodies specific for particular DC surface molecules. This can markedly enhance CTL responses and, via helper T cells, also enhance antibody responses. DC activation agents or adjuvants must also be administered for effective CTL responses, but in some cases good antibody responses can be obtained without adjuvants. Here we review the role of different DC subsets and different DC target molecules in obtaining enhanced immune responses.
KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY
SUBSETS IN-VIVO; C-TYPE LECTIN; STEADY-STATE; T-CELLS; CROSS-PRESENTATION; IFN-GAMMA; CD8(+); RESPONSES; IMMUNITY; CD4
10.3858/emm.2009.41.2.008
Refer to copyright notice on published article.

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Creation Date 2009-02-28 12:00:00