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'Knock, and it shall be opened': Knocking out and knocking in to reveal mechanisms of disease and novel therapies


Hacking, DF
2008-12
EARLY HUMAN DEVELOPMENT
Journal Article
84
12
821-827
Recent significant advances in molecular biology have generated genetically modified bacteria, yeast, nematodes, fruit flies, and fish. However, it is the genetic modification of mammalian model organisms, particularly the mouse, that has the greatest potential to shed light on human development, physiology and pathology in ways that have significant implications for neonatal and paediatric clinical practice. Here, we review some of the techniques for knocking out (inactivating), mutating and knocking in (inserting) selected genes that are important to neonatology and show how this research will lead both to a better understanding of disease and to novel therapies for infants and children. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
ELSEVIER IRELAND LTD
NOBEL-PRIZE; STEM-CELLS; MOUSE; MUTATIONS; MICE
10.1016/j.earlhumdev.2008.09.011
Refer to copyright notice on published article.

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Creation Date 2008-12-01 12:00:00