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Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma


Baum, J; Gilberger, TW; Frischknecht, F; Meissner, M
2008-12
TRENDS IN PARASITOLOGY
Journal Article
24
12
557-563
Recent years have seen tremendous progress in our understanding of malaria parasite molecular biology. To a large extent, this progress follows significant developments in genetic, molecular and chemical tools available to study the malaria parasites and related Apicomplexa, in particular Toxoplasma gondii. One area of major advancement has been in understanding parasite host-cell invasion, a process that utilizes several essential molecular mechanisms that are conserved across the different lifecycle stages. Here, we summarize some of the most recent experimental data that shed light on the events underlying preparation and execution of malaria parasite invasion and how these insights might relate to the development of new antimalarial drugs.
ELSEVIER SCI LTD
TRAP-LIKE PROTEIN; GONDII MYOSIN-A; RED-BLOOD-CELLS; APICOMPLEXAN PARASITES; ERYTHROCYTE INVASION; GLIDING MOTILITY; LIFE-CYCLE; SURFACE ADHESINS; MOVING JUNCTION; ABSCISIC-ACID
10.1016/j.pt.2008.08.006
Refer to copyright notice on published article.

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Creation Date 2008-12-01 12:00:00