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The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells


Loughran, SJ; Kruse, EA; Hacking, DF; de Graaf, CA; Hyland, CD; Willson, TA; Henley, KJ; Ellis, S; Voss, AK; Metcalf, D; Hilton, DJ; Alexander, WS; Kile, BT
2008-07
NATURE IMMUNOLOGY
Journal Article
9
7
810-819
Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of hematopoietic stem cell function and report here a germline mutation of Erg. We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers.
NATURE PUBLISHING GROUP
ACUTE MYELOID-LEUKEMIA; ETS-RELATED GENE; CONGENITAL AMEGAKARYOCYTIC THROMBOCYTOPENIA; GENOME-WIDE; C-MPL; DOWN-SYNDROME; MICE LACKING; MEGAKARYOBLASTIC LEUKEMIA; TARGETED DISRUPTION; PROGENITOR CELLS
10.1038/ni.1617
Refer to copyright notice on published article.

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Creation Date 2008-07-01 12:00:00