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Neuropeptide Y receptor-specifically modulates human neutrophil function


Bedoui, S; Kromer, A; Gebhardt, T; Jacobs, R; Raber, K; Dimitrijevic, M; Heine, J; von Horsten, S
2008-03
JOURNAL OF NEUROIMMUNOLOGY
Journal Article
195
1-2
88-95
Despite a continuously growing body of evidence highlighting the role of NPY in the immune system, surprisingly little is known about its ability to alter human leukocyte function. We therefore set out to examine NPY receptor expression and functional effects of NPY in freshly isolated human neutrophils. Our results not only demonstrate for the first time the presence of specific NPY receptors on human neutrophils, but also unveil of how these receptors differentially modulate critical functions of neutrophils such as phagocytosis of bacteria as well as the release of reactive oxygen species. (C) 2008 Elsevier B.V. All rights reserved.
ELSEVIER SCIENCE BV
IN-VIVO; PANCREATIC-POLYPEPTIDE; SYMPATHETIC-NERVE; IMMUNE-SYSTEM; PEPTIDE-YY; NPY; ACTIVATION; MONOCYTES; SHOCK; MOBILIZATION
10.1016/j.jneuroim.2008.01.012
Refer to copyright notice on published article.

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Creation Date 2008-03-01 12:00:00