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Activation of plasmacytoid dendritic cells


Fuchsberger, M; Hochrein, H; O'Keeffe, M
2005-10
IMMUNOLOGY AND CELL BIOLOGY
Journal Article
83
5
571-577
Four years after the discovery of mouse plasmacytoid dendritic cells (pDC), pDC are still very much an 'enigmatic' cell type. It is clear that pDC are potent producers of type I IFN in response to viral, bacterial and even mammalian nucleotides. The role that they play in vivo before and after activation is still under scrutiny. This review concentrates on the pathways to activation of pDC, examining the activating ligands, receptors and signalling molecules that are known to be involved, and the relevance of these activation pathways to human disease.
BLACKWELL PUBLISHING
IFN-ALPHA PRODUCTION; CHRONIC HEPATITIS-C; TOLL-LIKE RECEPTOR-7; INTERFERON-PRODUCING CELLS; VIRUS-INFECTION; FLT3 LIGAND; CPG DNA; INFLAMMATORY ARTHRITIS; MICROBIAL STIMULUS; VIRAL-INFECTION
10.1111/j.1440-1711.2005.01392.x
Refer to copyright notice on published article.

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Creation Date 2005-10-01 12:00:00