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Binding site for the C-domain of insulin-like growth factor (IGF) binding protein-6 on IGF-II; implications for inhibition of IGF actions


Headey, SJ; Keizer, DW; Yao, SG; Wallace, JC; Bach, LA; Norton, RS
2004-06-18
FEBS LETTERS
Journal Article
568
1-3
19-22
Insulin-like growth factors (IGFs) are important mediators of growth and IGF-binding proteins (IGFBPs) 1-6 regulate IGF actions. As lGFBP C-terminal domains contribute to high-affinity IGF binding, we have defined the binding site for the C-domain of IGFBP-6 on IGF-II using NMR. This site lies adjacent to and between the binding sites for the IGFBP N-domain and IGF-I receptor (IGFIR), which have previously been found on opposite sides of the IGF molecule. The C-domain is therefore likely to interfere with IGF binding to the IGFIR, providing a structural basis for the potent inhibitory effects of intact IGFBPs on IGF actions. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
ELSEVIER SCIENCE BV
DISEASE ANTIGEN OSPA; TERMINAL DOMAIN; RECEPTOR; EXPRESSION; MUTANTS; IDENTIFICATION; EPITOPES; DELETION; IGFBP-5; REGION
10.1016/j.febslet.2004.04.091
Refer to copyright notice on published article.

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Creation Date 2004-06-18 12:00:00