Research Publications

Back

Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty


Murray, JM; Kaufmann, GR; Hodgkin, PD; Lewin, SR; Kelleher, AD; Davenport, MP; Zaunders, JJ
2003-12
IMMUNOLOGY AND CELL BIOLOGY
Journal Article
81
6
487-495
Analysing T-cell receptor excision circle numbers in healthy individuals we find a marked change in the source of naive T cells before and after 20 years of age. The bulk of the naive T cell pool is sustained primarily from thymic output for individuals younger than 20 years of age whereas proliferation within the naive phenotype is dominant for older individuals. Over 90% of phenotypically naive T cells in middle age are not of direct thymic origin. Moreover, this change in source of naive T cells is accompanied either by an increased death rate of T cells from the thymus or reduced thymic export. Modelling of these processes shows that new naive T cells of a thymic origin have a half-life of approximately 50 days before this change occurs, and that either the life-span of recent thymic emigrants (but not necessarily of all naive cells) decreases approximately threefold in middle age, or thymic production drops by this same amount. The decay rate of T-cell receptor excision circle levels for individuals over 20 years of age is consistent with the decay rate of the productive thymus. Our modelling suggests that at age 25, thymic export is responsible for 20% of naive T-cell production and that this percentage decreases with the 15.7 year half-life of the productive thymus so that by age 55 only 5% of naive production arises from thymic export.
BLACKWELL PUBLISHING ASIA
RECEPTOR EXCISION CIRCLES; IMMUNE RECONSTITUTION; HIV-1 INFECTION; IN-VIVO; MEMORY; CD4(+); ADULT; REGENERATION; EMIGRANTS; SURVIVAL
10.1046/j.1440-1711.2003.01191.x
Refer to copyright notice on published article.

Back
Creation Date 2003-12-01 12:00:00