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Tetraspanins: molecular organisers of the leukocyte surface


Tarrant, JM; Robb, L; van Spriel, AB; Wright, MD
2003-11
TRENDS IN IMMUNOLOGY
Journal Article
24
11
610-617
Tetraspanins are a large superfamily of cell surface membrane proteins characterised by their four transmembrane domains. They are expressed in a wide variety of cell types and have functional roles in processes, such as cellular adhesion, motility, activation and tumour invasion. Leukocytes express less than or equal to20 tetraspanin proteins on their surface. Tetraspanins have an exceptional ability to interact with a diverse array of important proteins, such as integrins, immunoreceptors and signalling molecules. They are thought to organise a novel type of cell surface membrane microdomain, which in leukocytes functions to regulate activation, motility and antigen presentation. The importance of tetraspanin microdomains in immunity is highlighted by the perturbations in the immune system observed in tetraspanin-deficient mice.
ELSEVIER SCI LTD
MHC CLASS-II; T-CELL-ACTIVATION; TRANSMEMBRANE-4 SUPERFAMILY; SIGNAL-TRANSDUCTION; LIPID RAFTS; B-CELLS; ANTIPROLIFERATIVE ANTIBODY-1; PROLIFERATIVE RESPONSES; INTEGRIN ALPHA-3-BETA-1; MONOCLONAL-ANTIBODIES
10.1016/j.it.2003.09.011
Refer to copyright notice on published article.

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Creation Date 2003-11-01 12:00:00