Functional genomics: identifying drug targets for parasitic diseases
Cowman, AF; Crabb, BS
TRENDS IN PARASITOLOGY
The genomic sequences of parasitic diseases are rapidly becoming available and, recently, the full sequence of Plasmodium falciparum has been published. Much has been promised from this genomic revolution including the identification of new drug targets and novel chemotherapeutic treatments for the control of parasitic diseases. The challenge to use this information efficiently will require functional genomics tools such as bioinformatics, microarrays, proteomics and chemical genomics to identify potential drug targets,, and to allow the development of optimized lead compounds. The information generated from,these tools will provide. a crucial link from genomic analysis to drug discovery.
ELSEVIER SCI LTD
HUMAN MALARIA PARASITE; PLASMODIUM-FALCIPARUM; TRYPANOTHIONE REDUCTASE; CYSTEINE PROTEASES; TRYPANOSOMA-BRUCEI; OXIDATIVE STRESS; DNA MICROARRAYS; EXPRESSION; PATHWAY; TRANSFECTION