Research Publications

Back

Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1(G93A) (G1H) mouse model of familial amyotrophic lateral sclerosis


Azari, MF; Lopes, EC; Stubna, C; Turner, BJ; Zang, DW; Nicola, NA; Kurek, JB; Cheema, SS
2003-08-22
BRAIN RESEARCH
Journal Article
982
1
92-97
We investigated the anatomical and behavioural effects of daily intraperitoneal injection of 25 mug/kg of LIF in the SOD1(G93A G1H) mouse model of familial ALS. We found some subtle beneficial behavioural changes in LIF treated mice. These included later onset of clinical disease in females as determined by clinical scoring; better grip strength in males; and delayed development of motor impairment in males as determined by the rotarod test. However, we found no significant rescue of motoneurons or prolongation of survival as a result of this systemic dose of LIF in these mice. (C) 2003 Elsevier B.V. All rights reserved.
ELSEVIER SCIENCE BV
CILIARY NEUROTROPHIC FACTOR; MOTOR-NEURON DISEASE; INDUCED CELL-DEATH; FACTOR PREVENTS; FACTOR-RECEPTOR; MESSENGER-RNA; IN-VIVO; RAT; MOTONEURONS; BRAIN
10.1016/S0006-8993(03)02989-5
Refer to copyright notice on published article.

Back
Creation Date 2003-08-22 12:00:00