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The regulation of the development and function of dendritic cell subsets by GM-CSF: More than a hematopoietic growth factor


Zhan, YF; Xu, YK; Lew, AM
2012-08
MOLECULAR IMMUNOLOGY
Journal Article
52
1
30-37
Granulocyte-macrophage colony stimulating factor (GM-CSF) is a cytokine that functions as a hematopoietic growth factor for the generation of white blood cells and is used clinically to stimulate hematopoiesis following chemotherapy. Apart from stimulating production of granulocytes and monocytes/macrophages, GM-CSF has also long been used for in vitro survival/generation of dendritic cells (DCs) from monocytes and bone marrow cells. Evidence has emerged pointing to an additional role for GM-CSF in regulating the function and differential development of several DC subsets. These newly ascribed functions of GM-CSF may underscore its importance in immunity against pathogens as well as initiating/mediating immunopathology in chronic inflammation. Here we summarize recent advances on the role of GM-CSF in regulating the development and function of DC subsets and discuss the biological significance of these new findings. (C) 2012 Elsevier Ltd. All rights reserved.
PERGAMON-ELSEVIER SCIENCE LTD
COLONY-STIMULATING FACTOR; MYCOBACTERIUM-TUBERCULOSIS INFECTION; ANTIGEN-PRESENTING FUNCTIONS; COLLAGEN-INDUCED ARTHRITIS; LEUKEMIA INHIBITORY FACTOR; MOUSE LYMPHOID ORGANS; CD4 T-CELLS; IN-VIVO; CROSS-PRESENTATION; LANGERHANS CELLS
Immunology
10.1016/j.molimm.2012.04.009
Copyright © 2012 Elsevier Ltd. All rights reserved.