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Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E mu-v-abl transgenic mice


Symons, RCA; Daly, MJ; Fridlyand, J; Speed, TP; Cook, WD; Gerondakis, S; Harris, AW; Foote, SJ
2002-08-20
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Journal Article
99
17
11299-11304
There is a great difference insusceptibility to v-abl transgene-induced plasmacytoma between the BALB/cAn and the relatively resistant C57BL/6J mouse strains. We have used the Mapmaker/SURVIVOR algorithm to analyze genome-wide scans on over 800 transgenic F-2 hybrid mice, and have mapped at least six loci on chromosomes 2, 4, 11, 17, and 18 that modify tumor-related morbidity. As in human multiple myeloma, males were found to be more prone to plasmacytomagenesis. Different loci influence tumor susceptibility in male and female mice. Survival in females may be largely controlled by a pair of interacting loci on chromosomes 2 and 17.
NATL ACAD SCIENCES
MOUSE; RESISTANCE; TUMORIGENESIS; INDUCTION; IDENTIFICATION; CHROMOSOME-4; P16(INK4A); PRISTANE; PLA2G2A; REGION
10.1073/pnas.162566999
Refer to copyright notice on published article.