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The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes


Croker, BA; Tarlinton, DM; Cluse, LA; Tuxen, AJ; Light, A; Yang, FC; Williams, DA; Roberts, AW
2002-04-01
JOURNAL OF IMMUNOLOGY
Journal Article
168
7
3376-3386
We have defined roles for the hemopoietic-specific Rho guanosine triphosphatase, Rac2, in B lymphocyte development and function through examination of rac2(-/-) mice. Rac2-deficient mice displayed peripheral blood B lymphocytosis and marked reductions in peritoneal cavity B-la lymphocytes, marginal zone B lymphocytes, and IgM-secreting plasma cells as well as reduced concentrations of serum IgM and IgA. The rac2(-/-) B lymphocytes exhibited reduced calcium flux following coligation of B cell AgR and CD19 and reduced chemotaxis in chemokine gradients. T cell-independent responses to DNP-dextran were of reduced magnitude, but normal kinetics, in rac2(-/-) mice, while T-dependent responses to nitrophenyl-keyhole limpet hemocyanin were subtly abnormal. Rac2 is therefore an essential element in regulating B lymphocyte functions and maintaining B lymphocyte populations in vivo.
AMER ASSOC IMMUNOLOGISTS
PRIMARY IMMUNE-RESPONSE; T-CELL; SIGNAL-TRANSDUCTION; CHEMOKINE RECEPTOR; NEGATIVE REGULATOR; POSITIVE SELECTION; GERMINAL-CENTERS; MICE; CD19; VAV
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Creation Date 2002-04-01 12:00:00