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The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer


Visvader, JE; Venter, D; Hahm, K; Santamaria, M; Sum, EYM; O'Reilly, L; White, D; Williams, R; Armes, J; Lindeman, GJ
2001-12-04
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Journal Article
98
25
14452-14457
LM04 belongs to a family of LIM-only transcriptional regulators, the first two members of which are oncoproteins in acute T cell leukemia. We have explored a role for LM04, initially described as a human breast tumor autoantigen, in developing mammary epithelium and breast oncogenesis. Lmo4 was expressed predominantly in the lobuloalveoli of the mammary gland during pregnancy. Consistent with a role in proliferation, forced expression of this gene inhibited differentiation of mammary epithelial cells. Overexpression of LM04 mRNA was observed in 5 of 10 human breast cancer cell lines. Moreover, in situ hybridization analysis of 177 primary invasive breast carcinomas revealed overexpression of LM04 in 56% of specimens. immunohistochemistry confirmed overexpression in a high percentage (62%) of tumors. These studies imply a role for LM04 in maintaining proliferation of mammary epithelium and suggest that deregulation of this gene may contribute to breast tumorigenesis.
NATL ACAD SCIENCES
COMPARATIVE GENOMIC HYBRIDIZATION; COPY NUMBER; ERYTHROID DEVELOPMENT; HOMEODOMAIN PROTEINS; TRANSGENIC MICE; LEUKEMIA; TRANSLOCATIONS; IDENTIFICATION; AMPLIFICATION; EXPRESSION
10.1073/pnas.251547698
Refer to copyright notice on published article.

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Creation Date 2001-12-04 12:00:00