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Characterization of a human synovial cell antigen: VCAM-1 and inflammatory arthritis


Carter, RA; O'Donnell, K; Sachthep, S; Cicuttini, F; Boyd, AW; Wicks, IP
2001-09
IMMUNOLOGY AND CELL BIOLOGY
Journal Article
79
5
419-428
The contribution of synovial cells to the pathogenesis of rheumatoid arthritis (RA) is only partly understood. Monoclonal antibody (mAb) 1D5 is one of very few mAb ever raised against RA synovial cells in order to study the biology of these cells. Studies on the expression pattern and structural features of the 1D5 Ag suggest that 1D5 recognizes human vascular cell adhesion molecule-1 (VCAM-1), which is an intercellular adhesion molecule. Vascular cell adhesion molecule-1 may be involved in a number of crucial intercellular interactions in RA.
BLACKWELL SCIENCE ASIA
FIBROBLAST-LIKE SYNOVIOCYTES; INTERCELLULAR-ADHESION MOLECULE-1; FOLLICULAR DENDRITIC CELLS; CD4+ LYMPHOCYTES-T; HUMAN-B-CELLS; RHEUMATOID-ARTHRITIS; LEUKOCYTE ADHESION; SOLUBLE FORMS; E-SELECTIN; EXPRESSION
10.1046/j.1440-1711.2001.01019.x
Refer to copyright notice on published article.

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Creation Date 2001-09-01 12:00:00