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Interferon regulatory factor 1 is induced by interferon-gamma equally in neurons and glial cells


Thomas, HE; Dutton, R; Bartlett, PF; Kay, TWH
1997-09
JOURNAL OF NEUROIMMUNOLOGY
Journal Article
78
1-2
132-137
Class I MHC protein is induced in glia but not mature neurons by IFN-gamma. We have compared IFN-gamma signal transduction in these populations. There were identical levels of STAT1 homodimers and IRF-1 by gel-shift and IRF-1 mRNA was induced equally. However class I MHC, beta 2-microglobulin and interleukin 1-beta converting enzyme mRNA levels were greatly reduced in neurons. These experiments show that there is no defect in expression of IRF-1 in response to IFN-gamma in mature mouse neurons but that insufficient class I MHC gene expression is induced for detectable cell surface protein expression. (C) 1997 Elsevier Science B.V.
ELSEVIER SCIENCE BV
MHC CLASS-I; NF-KAPPA-B; BETA-2-MICROGLOBULIN GENE-EXPRESSION; APOPTOSIS; ANTIGENS; BRAIN; TRANSCRIPTION; INDUCTION; SEQUENCES; BINDING
10.1016/S0165-5728(97)00091-X
Refer to copyright notice on published article.

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Creation Date 1997-09-01 12:00:00