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Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division


Uren, AG; Beilharz, T; O'Connell, MJ; Bugg, SJ; van Driel, R; Vaux, DL; Lithgow, T
1999-08-31
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Journal Article
96
18
10170-10175
Inhibitors of apoptosis (IAPs) are a family of proteins that bear baculoviral IAP repeats (BIRs) and regulate apoptosis in vertebrates and Drosophila melanogaster. The yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe both encode a single IAP, designated BIR1 and bir1, respectively, each of which bears two BIRs. In rich medium, BIR1 mutant S,cerevisiae underwent normal vegetative growth and mitosis. Under starvation conditions, however, BIR1 mutant diploids formed spores inefficiently, instead undergoing pseudohyphal differentiation Most spores that did form failed to survive beyond two divisions after germination. bir1 mutant S. pombe spores also died in the early divisions after spore germination and became blocked at the metaphase/anaphase transition because of an inability to elongate their mitotic spindle, Rather than inhibiting caspase-mediated cell death, yeast IAP proteins have roles in cell division and appear to act in a similar way to the IAPs from Caenorhabditis elegans and the mammalian IAP Survivin.
NATL ACAD SCIENCES
SACCHAROMYCES-CEREVISIAE; BACULOVIRUS INHIBITOR; FISSION YEAST; SCHIZOSACCHAROMYCES-POMBE; MAMMALIAN-CELLS; IAP; GENE; HOMOLOGS; SURVIVIN; CASPASES
10.1073/pnas.96.18.10170
Refer to copyright notice on published article.

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Creation Date 1999-08-31 12:00:00