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Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF


Grell, M; Zimmermann, G; Gottfried, E; Chen, CM; Grunwald, U; Huang, DCS; Lee, YHW; Durkop, H; Engelmann, H; Scheurich, P; Wajant, H; Strasser, A
1999-06-01
EMBO JOURNAL
Journal Article
18
11
3034-3043
Several members of the tumour necrosis factor receptor (TNF-R) superfamily can induce cell death. For TNF-R1, Fas/APO-1, DR3, DR6, TRAIL-R1 and TRAIL-R2, a conserved 'death domain' in the intracellular region couples these receptors to activation of caspases, However, it is not yet known how TNF receptor family members lacking a death domain, such as TNF-R2, CD40, LT-beta R, CD27 or CD30, execute their death-inducing capability. Here we demonstrate in different cellular systems that cytotoxic effects induced by TNF-R2, CD40 and CD30 are mediated by endogenous production of TNF and autotropic or paratropic activation of TNF-R1, In addition, stimulation of TNF-R2 and CD40 synergistically enhances TNF-R1-induced cytotoxicity. These findings describe a novel pro-apoptotic mechanism induced by some members of the TNF-R family.
OXFORD UNIV PRESS
CYTOTOXIC T-LYMPHOCYTES; FACTOR-KAPPA-B; FACTOR-ALPHA; HODGKINS-DISEASE; FAS LIGAND; AUTOIMMUNE-DISEASE; SIGNALING COMPLEX; DOWN-REGULATION; LYMPHOID-CELLS; APOPTOSIS
10.1093/emboj/18.11.3034
Refer to copyright notice on published article.

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Creation Date 1999-06-01 12:00:00