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CD4+CD8+CD3HIGH THYMOCYTES APPEAR TRANSIENTLY DURING ONTOGENY - EVIDENCE FROM PHENOTYPIC AND FUNCTIONAL-STUDIES


HUGO, P; Boyd, RL; WAANDERS, GA; Scollay, R
1991-11
EUROPEAN JOURNAL OF IMMUNOLOGY
Journal Article
21
11
2655-2660
During T cell development thymocyte subsets emerge in a defined order, reflective of their maturational stage. In this study we determined the timing of appearance of CD4+CD8+CD3high thymocytes during in vivo and in vitro embryonic development, and thymic reconstitution after cortisone treatment. In these models, CD4+CD8+CD3high cells followed CD4+CD8+CD3low and preceded mature CD4+CD8-CD3high/CD4-CD8+CD3high thymocytes, while cortisone resistance was first seen among CD4+CD8+CD3high cells. CD4+CD8+CD3high thymocytes were also shown to display a pattern of antigen receptor-mediated calcium influx intermediate between that induced in other CD4+CD8+ cells and mature thymocytes. These results are consistent with a precursor-progeny relationship between CD4+CD8+CD3low and CD4+CD8+CD3high thymocytes, the latter developing to mature thymocytes (Hugo, P. et al., Int. Immunol. 1991. 3: 265).
VCH PUBLISHERS INC
CD3/T-CELL RECEPTOR COMPLEX; T-CELLS; IMMATURE THYMOCYTES; NEGATIVE SELECTION; POSITIVE SELECTION; CD4+8+ THYMOCYTES; TCR EXPRESSION; THYMUS; ANTIGEN; DIFFERENTIATION
10.1002/eji.1830211103
Refer to copyright notice on published article.

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Creation Date 1991-11-01 12:00:00