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CHARACTERIZATION OF IMMATURE CD4+CD8-CD3- THYMOCYTES


HUGO, P; WAANDERS, GA; Scollay, R; PETRIE, HT; Boyd, RL
1991-03
EUROPEAN JOURNAL OF IMMUNOLOGY
Journal Article
21
3
835-838
Previously we have described (Hugo, P. et al., Int. Immunol. 1990. 2: 209) an immature CD4+CD8-CD3- thymocyte subset which is thought to be the counterpart of the CD4-CD8+CD3- subset. In this study we show that the ontogeny of these two subsets is parallel in fetal thymic organ culture. Extensive phenotypic characterization of CD4+CD8-CD3- cells reveals that they closely resemble CD4-CD8+CD3- thymocytes being: HSA(high), Thy-1high, interleukin 2 receptor alpha chain negative, CD44-, H-2K +/-, CD5low, MEL-14low/intermediate, CD2+, LFA-1+ and MTS 35+. Finally, we show that the proportion of CD4+CD8-CD3- thymocytes is highly variable between mouse strains.
VCH PUBLISHERS INC
CELL-RECEPTOR EXPRESSION; MOUSE THYMOCYTES; DIFFERENTIATION; SUBSET; INTERMEDIATE; EVENTS; THYMUS
10.1002/eji.1830210346
Refer to copyright notice on published article.

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Creation Date 1991-03-01 12:00:00