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CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse


Wiede, F; Fromm, PD; Comerford, I; Kara, E; Bannan, J; Schuh, W; Ranasinghe, C; Tarlinton, D; Winkler, T; McColl, SR; Korner, H
2013-05
IMMUNOLOGY AND CELL BIOLOGY
Journal Article
91
5
335-339
The CC-chemokine receptor 6 (CCR6) is expressed constitutively at an intermediate level on naive B cells and is upregulated after activation on pregerminal center (GC) B cells. We hypothesized that it could be involved in the events leading to GC reaction and high-affinity antibody production, and therefore investigated the potential role of CCR6 in B-cell differentiation in vivo. After antigenic challenge of CCR6(-/-) mice with the T-cell-dependent antigen nitrophenyl-keyhole limpet hemocyanin (NP-KLH), GC B-cell development was found to be accelerated and the number of GC had increased significantly compared with control mice, but the antibodies produced by CCR6(-/-) B cells were on average of lower affinity. We conclude from these data that the CCR6/CCL20 axis has an important role in regulating the kinetics and efficiency of the GC reaction.
NATURE PUBLISHING GROUP
Immunology
10.1038/icb.2013.14
© 2013 Australasian Society for Immunology

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Creation Date 2013-05-01 12:00:00