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Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors


Sleebs, BE; Nikolakopoulos, G; Street, IP; Falk, H; Baell, JB
2011-10-01
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Journal Article
21
19
5992-5994
4-Aminobenzothieno[3,2-d]pyrimidines were previously identified in a high throughput screening campaign as LIMK1 inhibitors. Scaffold reversal led to the identification of a series of simple 5,6-substituted 4-aminothieno[2,3-d] pyrimidines with low micromolar inhibition of LIMK1. (C) 2011 Elsevier Ltd. All rights reserved.
PERGAMON-ELSEVIER SCIENCE LTD
KINASES
10.1016/j.bmcl.2011.07.050
Refer to copyright notice on published article.

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Creation Date 2011-10-01 12:00:00