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The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death.


Figgett, WA; Fairfax, K; Vincent, FB; Le Page, MA; Katik, I; Deliyanti, D; Quah, PS; Verma, P; Grumont, R; Gerondakis, S; Hertzog, P; O'Reilly, LA; Strasser, A; Mackay, F
2013-09-19
Immunity
Journal Article
39
3
573-583
Activation-induced cell death (AICD) plays a critical role in immune homeostasis and tolerance. In T-cell-dependent humoral responses, AICD of B cells is initiated by Fas ligand (FasL) on T cells, stimulating the Fas receptor on B cells. In contrast, T-cell-independent B cell responses involve innate-type B lymphocytes, such as marginal zone (MZ) B cells, and little is known about the mechanisms that control AICD during innate B cell responses to Toll-like receptor (TLR) activation. Here, we show that MZ B cells undergo AICD in response to TLR4 activation in vivo. The transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI) receptor and TLR4 cooperate to upregulate expression of both FasL and Fas on MZ B cells and also to repress inhibitors of Fas-induced apoptosis signaling. These findings demonstrate an unappreciated role for TACI and its ligands in the regulation of AICD during T-cell-independent B cell responses.
Cell Press
Molecular Genetics of Cancer
10.1016/j.immuni.2013.05.019
Copyright © 2013 Elsevier Inc. All rights reserved.

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Creation Date 2013-09-19 12:00:00