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Evolution of B cell responses to Clec9A-targeted antigen


Park, HY; Light, A; Lahoud, MH; Caminschi, I; Tarlinton, DM; Shortman, K
2013-11-15
Journal of immunology
Journal Article
191
10
4919-25
The response of B cells to Ag targeted to Clec9A on dendritic cells was followed using the hapten nitrophenol (NP) conjugated to rat Ig carrier. Injection of small amounts of NP conjugated to anti-Clec9A in the absence of adjuvants gave high and very prolonged Ab responses, approaching those obtained by high doses of nontargeted NP-protein conjugates with alum adjuvant. The response to NP-anti-Clec9A included the transient formation of germinal centers, maturation of Ab affinity, and some memory B cell formation. Serum Ab titers remained high 35 wk postimmunization, well after the initial follicular response had faded. The results suggest Clec9A-targeting strategies for improving Ab responses to vaccine Ags.
AMER ASSOC IMMUNOLOGISTS
Immunology
10.4049/jimmunol.1301947
Copyright ©2014 by The American Association of Immunologists, Inc. All rights reserved

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Creation Date 2014-02-18 03:39:53