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Circulating Levels of the Wnt Antagonist Dkk-3 as a Diagnostic Marker for Colorectal Cancer


Brierley, GV; Fung, KYC; Purins, L; Priebe, IK; Tabor, B; Lockett, T; Nice, E; Gibbs, P; Tie, J; McMurrick, P; Moore, J; Ruszkiewicz, AR; Burgess, A; Cosgrove, LJ
2013-06
Journal of Molecular Biomarkers & Diagnosis
Journal Article
S8-008
The Wnt antagonist Dickkopf-3 (Dkk-3) has been implicated in several stages of tumour development in a wide; range of human cancers, including colorectal cancer (CRC). However, the usefulness of serum Dkk-3 levels as a; diagnostic biomarker for CRC has yet to be determined. In this study we used an ELISA immunoassay to examine; serum Dkk-3 protein levels in a retrospective cohort of CRC patients (n = 89) and age, gender matched controls (n; = 46). The median concentration of Dkk-3 was significantly (p = 0.0003) lower in CRC patient serum samples (29.3; ng/ml, range 10.4 – 67.8 ng/ml) when compared to control serum samples (36.8 ng/ml, range 20.7 – 67.4 ng/ml).; Receiver operating characteristic analysis demonstrated at 90% specificity, serum Dkk-3 levels distinguished CRC; patients with 36% sensitivity (AUC = 0.69, 95% CI 0.60 – 0.78).
OMICS Publishing Group
Colorectal cancer; Diagnostic biomarker; Dickkopf–3; Dkk–3
Structural Biology
10.4172/2155-9929.S8-008
Copyright: © 2013 Brierley GV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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Creation Date 2014-02-27 01:08:04