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Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations.


Mouradov, D; Domingo, E; Gibbs, P; Jorissen, RN; Li, S; Soo, PY; Lipton, L; Desai, J; Danielsen, HE; Oukrif, D; Novelli, M; Yau, C; Holmes, CC; Jones, IT; McLaughlin, S; Molloy, P; Hawkins, NJ; Ward, R; Midgely, R; Kerr, D; Tomlinson, IP; Sieber, OM
2013-11
The American journal of gastroenterology
Journal Article
108
11
1785-93
Microsatellite instability (MSI) is an established marker of good prognosis in colorectal cancer (CRC). Chromosomal instability (CIN) is strongly negatively associated with MSI and has been shown to be a marker of poor prognosis in a small number of studies. However, a substantial group of "double-negative" (MSI-/CIN-) CRCs exists. The prognosis of these patients is unclear. Furthermore, MSI and CIN are each associated with specific molecular changes, such as mutations in KRAS and BRAF, that have been associated with prognosis. It is not known which of MSI, CIN, and the specific gene mutations are primary predictors of survival.
NPG
Systems Biology and Personalised Medicine
10.1038/ajg.2013.292
© 2014 The American College of Gastroenterology