Research Publications

Back

The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation


Carotta, S; Willis, SN; Hasbold, J; Inouye, M; Pang, SH; Emslie, D; Light, A; Chopin, M; Shi, W; Wang, H; Morse, HC, 3rd; Tarlinton, DM; Corcoran, LM; Hodgkin, PD; Nutt, SL
2014-10-06
J Exp Med
Journal Article
211
11
2169-81
Activated B cells undergo immunoglobulin class-switch recombination (CSR) and differentiate into antibody-secreting plasma cells. The distinct transcriptomes of B cells and plasma cells are maintained by the antagonistic influences of two groups of transcription factors: those that maintain the B cell program, including BCL6 and PAX5, and plasma cell-promoting factors, such as IRF4 and BLIMP-1. We show that the complex of IRF8 and PU.1 controls the propensity of B cells to undergo CSR and plasma cell differentiation by concurrently promoting the expression of BCL6 and PAX5 and repressing AID and BLIMP-1. As the PU.1-IRF8 complex functions in a reciprocal manner to IRF4, we propose that concentration-dependent competition between these factors controls B cell terminal differentiation.
Rockefeller University Press
Molecular Immunology; Immunology
10.1084/jem.20140425
Refer to article for additional funding acknowledgements
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org.ezp.lib.unimelb.edu.au/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

Back
Creation Date 2014-10-13 02:21:48 Last Modified 2015-05-25 11:35:03