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Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission


Teo, A; Hasang, W; Randall, LM; Unger, HW; Siba, PM; Mueller, I; Brown, GV; Rogerson, SJ
2015
Malaria Journal
Journal Article
14
1
215
BACKGROUND: Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. METHODS: Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of SP with azithromycin. RESULTS: Malaria prevalence was low. Between enrolment and delivery, antibodies to recombinant antigens declined in both groups (p < 0.0001). In contrast, median levels of opsonizing antibodies did not change, although levels for some individuals changed significantly. In multivariate analysis, the malaria prevention regimen did not influence antibody levels. CONCLUSION: Different preventive anti-malarial chemotherapy regimens used during pregnancy had limited impact on malarial-immunity in a low-transmission region of Papua New Guinea. TRIAL REGISTRATIONS: NCT01136850.
BioMed Central
Population Health and Immunity
10.1186/s12936-015-0736-x
26006260
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Creation Date 2015-06-15 09:53:30 Last Modified 2019-04-01 09:10:59