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CD8(+) T cell help is required for efficient induction of EAE in Lewis rats


Camara, M; Beyersdorf, N; Fischer, HJ; Herold, MJ; Ip, CW; van den Brandt, J; Toyka, KV; Taurog, JD; Hunig, T; Herrmann, T; Reichardt, HM; Weishaupt, A; Kerkau, T
2013-07-15
JOURNAL OF NEUROIMMUNOLOGY
Journal Article
260
1-2
17-27
The role of CD8(+) T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats, depleted of CD8(+) T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte infiltration into the spinal cord. We detected myelin basic protein (MBP)-specific CD4(+) T cells in peripheral lymphoid organs of CD8-depleted animals which, however, failed to differentiate into interferon-gamma-producing effector cells. Our results indicate that CD8(+) T cells interact with myelin-specific CD4(+) T cells early in EAE enabling them to differentiate into pathogenic effector cells. (C) 2013 Elsevier B.V. All rights reserved.
ELSEVIER SCIENCE BV
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MYELIN BASIC-PROTEIN; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; CORTICAL DEMYELINATION; MONOCLONAL-ANTIBODIES; IMMUNE TOLERANCE; ANTIGEN THERAPY; INFLAMMATION
Molecular Genetics of Cancer
10.1016/j.jneuroim.2013.04.014
Copyright © 2013 Elsevier B.V. All rights reserved.

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Creation Date 2013-07-15 12:00:00