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Lethal giant larvae-1 deficiency enhances the CD8 effector T-cell response to antigen challenge in vivo


Ramsbottom, KM; Sacirbegovic, F; Hawkins, ED; Kallies, A; Belz, GT; Van Ham, V; Haynes, NM; Durrant, MJ; Humbert, PO; Russell, SM; Oliaro, J
2015-09-22
Immunol Cell Biol
Journal Article in press
Lethal giant larvae-1 (Lgl-1) is an evolutionary conserved protein that regulates cell polarity in diverse lineages; however, the role of Lgl-1 in the polarity and function of immune cells remains to be elucidated. To assess the role of Lgl-1 in T cells, we generated chimeric mice with a hematopoietic system deficient for Lgl-1. Lgl-1 deficiency did not impair the activation or function of peripheral CD8+ T cells in response to antigen presentation in vitro, but did skew effector and memory T-cell differentiation. When challenged with antigen-expressing virus or tumor, Lgl-1-deficient mice displayed altered T-cell responses. This manifested in a stronger antiviral and antitumor effector CD8+ T-cell response, the latter resulting in enhanced control of MC38-OVA tumors. These results reveal a novel role for Lgl-1 in the regulation of virus-specific T-cell responses and antitumor immunity.Immunology and Cell Biology advance online publication, 22 September 2015; doi:10.1038/icb.2015.82.
NPG
Molecular Immunology
10.1038/icb.2015.82
26391810
Refer to copyright notice on published article.

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Creation Date 2015-10-23 03:05:37 Last Modified 2015-10-26 12:02:29