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Multiple Plasmodium falciparum merozoite surface protein 1 complexes mediate merozoite binding to human erythrocytes


Lin, CS; Uboldi, AD; Epp, C; Bujard, H; Tsuboi, T; Czabotar, PE; Cowman, AF
2016-04
2016-01-28
Journal of Biological Chemistry
Journal Article
291
14
7703-15
Successful invasion of human erythrocytes by P. falciparum merozoites is required for infection of the host and parasite survival. The early stages of invasion are mediated via merozoite surface proteins that interact with human erythrocytes. The nature of these interactions are currently not well understood, but it is known that Merozoite Surface Protein 1 (MSP1) is critical for successful erythrocyte invasion. Here, we show that the peripheral merozoite surface proteins MSP3, MSP6, MSPDBL1, MSPDBL2 and MSP7 bind directly to MSP1, but independently of each other, to form multiple forms of the MSP1 complex on the parasite surface. These complexes have overlapping functions that interact directly with human erythrocytes. We also show that targeting the p83 fragment of MSP1 using inhibitory antibodies inhibits all forms of MSP1 complexes and disrupts parasite growth in vitro.
ASBMB
Structural Biology; Infection and Immunity
10.1074/jbc.M115.698282
26823464
Refer to copyright notice on published article.

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Creation Date 2016-03-14 03:05:31 Last Modified 2018-07-04 03:06:14