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The NF-kappaB transcription factor RelA is required for the tolerogenic function of Foxp3 regulatory T cells


Messina, N; Fulford, T; O'Reilly, L; Loh, WX; Motyer, JM; ELLIS, D; McLean, C; Naeem, H; Lin, A; Gugasyan, R; Slattery, RM; Grumont, RJ; Gerondakis, S
2016-04-07
J Autoimmun
Journal Article in press
The properties of CD4+ regulatory T cell (Treg) subsets are dictated by distinct patterns of gene expression determined by FOXP3 and different combinations of various transcription factors. Here we show the NF-kappaB transcription factor RelA is constitutively active in naive and effector Tregs. The conditional inactivation of Rela in murine FOXP3+ cells induces a rapid onset, multi-focal autoimmune disease that depends on RelA being expressed in conventional T cells. In addition to promoting Treg lineage stability, RelA determines the size of the effector Treg population, a function influenced by the presence or absence of RelA in conventional T cells. These findings showing that RelA controls Treg stability and promotes the competitive fitness of effector Tregs highlight the importance of RelA activity in peripheral Treg induced tolerance.
Elsevier
Molecular Genetics of Cancer
10.1016/j.jaut.2016.03.017
27068879
Refer to copyright notice on published article.

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Creation Date 2016-04-28 02:06:57 Last Modified 2016-05-02 08:37:40