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Genomic epidemiology of artemisinin resistant malaria


Amato, R; Miotto, O; Woodrow, CJ; Almagro-Garcia, J; Sinha, I; Campino, S; Mead, D; Drury, E; Kekre, M; Sanders, M; Amambua-Ngwa, A; Amaratunga, C; Amenga-Etego, L; Andrianaranjaka, V; Apinjoh, T; Ashley, E; Auburn, S; Awandare, GA; Baraka, V; Barry, A; Boni, MF; Borrmann, S; Bousema, T; Branch, O; Bull, PC; Chotivanich, K; Conway, DJ; Craig, A; Day, NP; Djimde, A; Dolecek, C; Dondorp, AM; Drakeley, C; Duffy, P; Echeverry, DF; Egwang, TG; Fairhurst, RM; Faiz, MA; Fanello, CI; Hien, TT; Hodgson, A; Imwong, M; Ishengoma, D; Lim, P; Lon, C; Marfurt, J; Marsh, K; Mayxay, M; Michon, P; Mobegi, V; Mokuolu, OA; Montgomery, J; Mueller, I; Kyaw, MP; Newton, PN; Nosten, F; Noviyanti, R; Nzila, A; Ocholla, H; Oduro, A; Onyamboko, M; Ouedraogo, JB; Phyo, APP; Plowe, C; Price, RN; Pukrittayakamee, S; Randrianarivelojosia, M; Ringwald, P; Ruiz, L; Saunders, D; Shayo, A; Siba, P; Takala-Harrison, S; Thanh, TNN; Thathy, V; Verra, F; Wendler, J; White, NJ; Ye, H; Cornelius, VJ; Giacomantonio, R; Muddyman, D; Henrichs, C; Malangone, C; Jyothi, D; Pearson, RD; Rayner, JC; McVean, G; Rockett, KA; Miles, A; Vauterin, P; Jeffery, B; Manske, M; Stalker, J; Maclnnis, B; Kwiatkowski, DP
2016
Elife
Journal Article
5
pii: e08714
The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelchl3 mutations which cause resistance in Southeast Asia are present at low frequency in Africa. We show that African kelch13 mutations have originated locally, and that kelch13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-acid changes. Thus, kelch13 is not currently undergoing strong selection in Africa, despite a deep reservoir of variations that could potentially allow resistance to emerge rapidly. The practical implications are that public health surveillance for artemisinin resistance should not rely on kelchl3 data alone, and interventions to prevent resistance must account for local evolutionary conditions, shown by genomic epidemiology to differ greatly between geographical regions.
elife Sciences
Population Health and Immunity
10.7554/eLife.08714
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Creation Date 2016-06-15 08:51:07 Last Modified 2016-06-15 08:57:41