The linkage between T-cell and dendritic cell development in the mouse thymus
- Author(s)
- Shortman, K; Vremec, D; Corcoran, LM; Georgopoulos, K; Lucas, K; Wu, L;
- Journal Title
- IMMUNOLOGICAL REVIEWS
- Publication Type
- Journal Article
- Abstract
- Thymic dendritic cells (DC) mediate negative selection at a relatively late stage of the T-cell developmental pathway. We present evidence that the development of thymic DC and of T-lineage cells is linked via a common precursor at an early stage of thymocyte development. T-lineage precursor populations from the adult mouse thymus, prior to T-cell receptor gene rearrangement, display a capacity to produce DC as well as T cells in the thymus, and are very efficient precursors of DC in culture. These lymphoid/DC precursors have little capacity to form myeloid cells, indicating that thymic DC are a lymphoid-related rather than myeloid-related lineage. In contrast to myeloid-related DC, granulocyte-macrophage colony-stimulating factor is not required for the development of these lymphoid-related DC in vivo or in vitro. DC can develop in mutant mice lacking mature T cells, provided the common precursors are present. However, in mutant mice lacking functional Ikaros transcription factors, there are deficiencies in lymphoid precursor cells, in mature lymphoid cells and in DC.
- Publisher
- MUNKSGAARD INT PUBL LTD
- Keywords
- COLONY-STIMULATING FACTOR; PRECURSOR CELLS; NEGATIVE SELECTION; LINEAGE COMMITMENT; LYMPHOID ORGANS; SURFACE-MARKERS; NATURAL-KILLER; CD8 EXPRESSION; IKAROS GENE; STEM-CELLS
- Publisher's Version
- https://doi.org/10.1111/j.1600-065X.1998.tb01228.x
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- Refer to copyright notice on published article.
Creation Date: 1998-10-01 12:00:00