Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response are required for generation of immunity to leishmaniasis
- Author(s)
- Sjolander, A; Baldwin, TM; Curtis, JM; Handman, E;
- Details
- Publication Year 1998-04-15,Volume 160,Issue #8,Page 3949-3957
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Experimental systems based on immunization with plasmid DNA or immune-stimulating complexes were used to delineate the requirements for generation of protective immunity against murine leishmaniasis. Vaccination with plasmid DNA encoding the host-protective Leishmania major parasite surface Ag-2 primed for an essentially exclusive Th1 response that protected mice against L, major infection, In contrast, parasite surface Ag-2 in immune-stimulating complexes generated an immune response with mixed Th1-like and Th2-like properties that was not protective despite the activation of large numbers of CD4(+) T cells secreting IFN-gamma, These results indicate that a Th1 response is sufficient to protect against cutaneous leishmaniasis, but the induction of a simultaneous Th2 response abrogates the Th1 effector function, DNA vaccines may therefore have an advantage for diseases in which protection depends on the induction of Th1 responses.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- MURINE CUTANEOUS LEISHMANIASIS; T-CELL SUBSETS; INTERFERON-GAMMA; IMMUNOSTIMULATING COMPLEXES; SURFACE-ANTIGEN; PROMASTIGOTE SURFACE-ANTIGEN-2; ADJUVANT ACTIVITY; BALB/C MICE; PLASMID DNA; NUDE-MICE
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Creation Date: 1998-04-15 12:00:00