Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response are required for generation of immunity to leishmaniasis
Details
Publication Year 1998-04-15,Volume 160,Issue #8,Page 3949-3957
Journal Title
JOURNAL OF IMMUNOLOGY
Publication Type
Journal Article
Abstract
Experimental systems based on immunization with plasmid DNA or immune-stimulating complexes were used to delineate the requirements for generation of protective immunity against murine leishmaniasis. Vaccination with plasmid DNA encoding the host-protective Leishmania major parasite surface Ag-2 primed for an essentially exclusive Th1 response that protected mice against L, major infection, In contrast, parasite surface Ag-2 in immune-stimulating complexes generated an immune response with mixed Th1-like and Th2-like properties that was not protective despite the activation of large numbers of CD4(+) T cells secreting IFN-gamma, These results indicate that a Th1 response is sufficient to protect against cutaneous leishmaniasis, but the induction of a simultaneous Th2 response abrogates the Th1 effector function, DNA vaccines may therefore have an advantage for diseases in which protection depends on the induction of Th1 responses.
Publisher
AMER ASSOC IMMUNOLOGISTS
Keywords
MURINE CUTANEOUS LEISHMANIASIS; T-CELL SUBSETS; INTERFERON-GAMMA; IMMUNOSTIMULATING COMPLEXES; SURFACE-ANTIGEN; PROMASTIGOTE SURFACE-ANTIGEN-2; ADJUVANT ACTIVITY; BALB/C MICE; PLASMID DNA; NUDE-MICE
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Creation Date: 1998-04-15 12:00:00
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