Inhibition of the B cell by CD22: A requirement for Lyn
- Author(s)
- Smith, KGC; Tarlinton, DM; Doody, GM; Hibbs, ML; Fearon, DT;
- Details
- Publication Year 1998-03-02,Volume 187,Issue #5,Page 807-811
- Journal Title
- JOURNAL OF EXPERIMENTAL MEDICINE
- Publication Type
- Journal Article
- Abstract
- Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the absence of Lyn, the ability of CD22 to become tyrosine phosphorylated after Ligation of mIg, to recruit SHP-1, and to suppress mig-induced elevation of intracellular [Ca2+] is lost. Therefore, Lyn is required for the SHP-1-mediated B cell suppressive function of CD22, accounting for similarities in the phenotypes of these mice.
- Publisher
- ROCKEFELLER UNIV PRESS
- Keywords
- PROTEIN-TYROSINE KINASES; ANTIGEN RECEPTOR; DEFICIENT MICE; AUTOIMMUNE-DISEASE; PHOSPHATASE 1C; ASSOCIATION; ACTIVATION; LYMPHOCYTES; RESPONSES; SELECTION
- Publisher's Version
- https://doi.org/10.1084/jem.187.5.807
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1998-03-02 12:00:00