Apical membrane antigen 1: A leading malaria vaccine candidate
- Author(s)
- Anders, RF; Crewther, PE; Hodder, AN;
- Details
- Publication Year 1998-03,Volume 8,Issue #2,Page 91-95
- Journal Title
- AUSTRALASIAN BIOTECHNOLOGY
- Publication Type
- Journal Article
- Abstract
- The development of a malaria vaccine remains one of the world's major public health priorities. Numerous proteins in several different life cycle stages have been identified as potential vaccine components. In the asexual blood stages of Plasmodium falciparum two antigens, merozoite surface protein 1 (MSP1) and apical membrane antigen 1 (AMA1) stand out as the leading vaccine candidates because of the extensive assessment of shown that AMA1 can induce antibody-mediated protective immune responses. Diversity in AMA1 exists but whether this limits the efficacy of an AMA1 vaccine will need to be examined in clinical trials carried out in areas where malaria in is endemic.
- Publisher
- AUSTRALIAN BIOTECHNOLOGY ASSOC LTD
- Keywords
- PLASMODIUM-KNOWLESI; MEROZOITE ANTIGEN
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1998-03-01 12:00:00