INTERACTION OF INTERLEUKIN-6, TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-1 DURING LISTERIA INFECTION
- Author(s)
- LIU, Z; Simpson, RJ; Cheers, C;
- Details
- Publication Year 1995-08,Volume 85,Issue #4,Page 562-567
- Journal Title
- IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Injected recombinant interleukin-6 (IL-6), tumour necrosis factor (TNF) and IL-1 all protect mice against experimental infection with Listeria monocy,togenes. We have therefore investigated the interaction of these cytokines during infection. Treatment with recombinant (r)IL-6 enhanced TNF production by spleen cells during the first 2 days of infection. Anti-TNF antibody could totally abolish the protective effect of rIL-6, while the optimal protective function of TNF could not be achieved when IL-6 was neutralized by anti-IL-6 antibody. IL-1 induced a high level of IL-6 in the serum a short time after its administration, and neutralization of IL-6 totally abolished the protective function of rIL-1. The results thus provide further evidence for the complexity of cytokine interaction.
- Publisher
- BLACKWELL SCIENCE LTD
- Keywords
- ANTIBACTERIAL RESISTANCE; MURINE LISTERIOSIS; GAMMA-INTERFERON; MONOCYTOGENES INFECTION; HOST-RESISTANCE; SCID MICE; IL-6; CYTOKINES; NEUTROPHILS; MECHANISMS
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Creation Date: 1995-08-01 12:00:00