Leukemia inhibitory factor maintains choline acetyltransferase expression in vivo

Author(s): Cheema, SS; Arumugam, D; Murray, SS; Bartlett, PF;
Details: Publication Year 1998-02-16,Volume 9,Issue #3,Page 363-366
Journal Title: NEUROREPORT
Publication Type: Journal Article
Abstract: FOLLOWING axotomy most medial septal neurons in the adult rat brain have dramatically reduced numbers of choline acetyltransferase (ChAT) positive neurons. Since leukemia inhibitory factor (LIF) promotes cholinergic expression in several neuronal populations, the aim of this study was to determine if LIF would continue to support cholinergic expression in axotomized medial septal neurons. Mini-osmotic pumps were used to infuse saline or LIF into the lateral cerebral ventricle. Counts of ChAT and low-affinity nerve growth factor (p75NGFR) immunostained neurons indicated that LIF-treated animals retained ChAT expression in > 90% of axotomized neurons whereas in saline-infused animals this was < 30%. Also, LIF was equally effective in maintaining p75NGFR expression levels in axotomized medial septal neurons. (C) 1998 Rapid Science Ltd.
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Keywords: NERVE GROWTH-FACTOR; ADULT-RAT BRAIN; FACTOR PREVENTS; DIFFERENTIATION FACTOR; SPINAL-CORD; NEURONAL DEGENERATION; RETROGRADE TRANSPORT; IN-VITRO; LIF; RECEPTOR
Publisher's Version: https://doi.org/10.1097/00001756-199802160-00001
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1998-02-16 12:00:00