Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation
- Author(s)
- Robb, L; Li, RL; Hartley, L; Nandurkar, HH; Koentgen, F; Begley, CG;
- Details
- Publication Year 1998-03,Volume 4,Issue #3,Page 303-308
- Journal Title
- NATURE MEDICINE
- Publication Type
- Journal Article
- Abstract
- During early pregnancy, ir! response to the implanting embryo, the surrounding uterine stroma undergoes a dramatic transformation into a specialized tissue known as the decidua. The decidua encapsulates the developing embryo, facilitating nutrient transfer and limiting trophoblast invasion. Here we show that female mice with a null mutation of the interleukin-11 receptor alpha chain are infertile because of defective decidualization. A temporal analysis revealed IL-11 expression is maximal in the normal pregnant uterus at the time of decidualization, and in situ hybridization studies showed expression of the IL-11 and the IL-ll receptor alpha chain in the developing decidual cells. These observations reveal a previously unrecognized critical role for IL-ll signaling in female reproduction.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- LEUKEMIA INHIBITORY FACTOR; BLASTOCYST IMPLANTATION; ALPHA-CHAIN; EXPRESSION; METALLOPROTEINASES; REQUIREMENT; PREGNANCY; CLONING; INVITRO; EMBRYO
- Publisher's Version
- https://doi.org/10.1038/nm0398-303
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1998-03-01 12:00:00