Help for cytotoxic-T-cell responses is mediated by CD40 signalling
- Author(s)
- Bennett, SRM; Carbone, FR; Karamalis, F; Flavell, RA; Miller, JFAP; Heath, WR;
- Details
- Publication Year 1998-06-04,Volume 393,Issue #6684,Page 478-480
- Journal Title
- NATURE
- Publication Type
- Journal Article
- Abstract
- Cytotoxic T lymphocytes (CTLs) which carry the CD8 antigen recognize antigens that are presented on target cells by the class I major histocompatibility complex. CTLs are responsible for the killing of antigen-bearing target cells, such as virus-infected cells. Although CTL effecters can act alone when killing target cells, their differentiation from naive CD8-positive T cells is often dependent on 'help' from CD4-positive helper T (T-H) cells(1-4).Furthermore, for effective CTL priming, this help must be provided in a cognate manner, such that both the T-H cell and the CTL recognize antigen on the same antigen-presenting cell(2,4). One explanation for this requirement is that T-H cells are needed to convert the antigen-presenting cell into a cell that is fully competent to prime CTL5. Here we show that signalling through CD40 on the antigen-presenting cells can replace the requirement for T-H cells, indicating that T-cell 'help', at least for generation of CTLs by cross-priming, is mediated by signalling through CD40 on the antigen-presenting cell.
- Publisher
- MACMILLAN MAGAZINES LTD
- Keywords
- CD40-CD40 LIGAND INTERACTION; ANTIBODY-RESPONSES; HUMAN MONOCYTES; CD8(+) CTL; MICE; ACTIVATION; INDUCTION; INVIVO; LYMPHOCYTES; REQUIREMENT
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Creation Date: 1998-06-04 12:00:00