MAG and MOG enhance neurite outgrowth of embryonic mouse spinal cord neurons

Author(s): Turnley, AM; Bartlett, PF;
Details: Publication Year 1998-06-22,Volume 9,Issue #9,Page 1987-1990
Journal Title: NEUROREPORT
Publication Type: Journal Article
Abstract: MYELIN-ASSOCIATED glycoprotein (MAG) inhibits neurite outgrowth of postnatal spinal cord neurons, but its effect on embryonic neurons is unknown. The effect on neurite outgrowth of another myelin protein, myelin-oligodendrocyte glycoprotein (MOG) is also unknown. We determined the effect of MAG and MOG on embryonic day 17 spinal cord neurons, which were cultured on MAG, MOG or control transfected CHO cells. Neurite outgrowth was examined and both total neurite length and longest neurite length were significantly enhanced by both MAG and MOG. These findings show that, in contrast to postnatal spinal cord neurons, MAG can enhance neurite outgrowth of embryonic spinal cord neurons. In addition, another myelin protein, MOG, can also modulate neurite outgrowth. (C) 1998 Rapid Science Ltd.
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Keywords: MYELIN-ASSOCIATED GLYCOPROTEIN; AXONAL REGENERATION; INHIBITOR; EXPRESSION; GROWTH; OLIGODENDROCYTES; ADHESION; PROTEIN; ZONE; TUBE
Publisher's Version: https://doi.org/10.1097/00001756-199806220-00013
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1998-06-22 12:00:00