Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells

Author(s): Hawkins, CJ; Ekert, PG; Uren, AG; Holmgreen, SP; Vaux, DL;
Details: Publication Year 1998-07,Volume 5,Issue #7,Page 569-576
Journal Title: CELL DEATH AND DIFFERENTIATION
Publication Type: Journal Article
Abstract: IAPs were identified as baculoviral proteins that could inhibit the apoptotic response of insect cells to infection. Of the viral IAPs, OpIAP and CpIAP can inhibit apoptosis, whereas AcIAP cannot. OpIAP and some mammalian homologues can inhibit mammalian cell death. Two mammalian IAPs bind to TNFRII associated factors (TRAFs), but the significance of this is unclear. Here we show that Drosophila cellular IAPs and two baculoviral IAPs (OpIAP and CpIAP) can inhibit mammalian cell death induced by overexpression of Caspases 1 and 2, IAPs must act on conserved components of the apoptotic mechanism, but as none of these IAPs could bind TRAF proteins, TRAFs are not likely to be important for IAP mediated apoptosis inhibition. As OpIAP protected against death induced by ligation of TNF receptor family members, but not by factor nor serum withdrawal from dependent cells, it can inhibit certain apoptotic pathways without affecting others.
Publisher: STOCKTON PRESS
Keywords: NECROSIS-FACTOR RECEPTOR; DEATH GENE CED-3; C-ELEGANS; INHIBITORY PROTEIN; BACULOVIRUS GENE; FAMILY; ENZYME; BCL-2; P35; PROTEASES
Publisher's Version: https://doi.org/10.1038/sj.cdd.4400389
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1998-07-01 12:00:00