Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells
Details
Publication Year 1998-07,Volume 5,Issue #7,Page 569-576
Journal Title
CELL DEATH AND DIFFERENTIATION
Publication Type
Journal Article
Abstract
IAPs were identified as baculoviral proteins that could inhibit the apoptotic response of insect cells to infection. Of the viral IAPs, OpIAP and CpIAP can inhibit apoptosis, whereas AcIAP cannot. OpIAP and some mammalian homologues can inhibit mammalian cell death. Two mammalian IAPs bind to TNFRII associated factors (TRAFs), but the significance of this is unclear. Here we show that Drosophila cellular IAPs and two baculoviral IAPs (OpIAP and CpIAP) can inhibit mammalian cell death induced by overexpression of Caspases 1 and 2, IAPs must act on conserved components of the apoptotic mechanism, but as none of these IAPs could bind TRAF proteins, TRAFs are not likely to be important for IAP mediated apoptosis inhibition. As OpIAP protected against death induced by ligation of TNF receptor family members, but not by factor nor serum withdrawal from dependent cells, it can inhibit certain apoptotic pathways without affecting others.
Publisher
STOCKTON PRESS
Keywords
NECROSIS-FACTOR RECEPTOR; DEATH GENE CED-3; C-ELEGANS; INHIBITORY PROTEIN; BACULOVIRUS GENE; FAMILY; ENZYME; BCL-2; P35; PROTEASES
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 1998-07-01 12:00:00
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