Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16
- Cavanaugh, JA; Callen, DF; Wilson, SR; Stanford, PM; Sraml, ME; Gorska, M; Crawford, J; Whitmore, SA; Shlegel, C; Foote, S; Kohonen-Corish, AD; Pavli, P;
- Journal Title
- ANNALS OF HUMAN GENETICS
- Publication Type
- Journal Article
- A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan; Hugot et al. (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis (Ohmen et al. 1996; Parkes et al. 1996). We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crokn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753.
- CAMBRIDGE UNIV PRESS
- COMPLEX SEGREGATION ANALYSIS; ULCERATIVE-COLITIS; LINKAGE ANALYSIS; GENETIC-LINKAGE; STRATEGIES; LOCUS
- Publisher's Version
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Creation Date: 1998-07-01 12:00:00Last Modified: 0001-01-01 12:00:00