Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response
- Author(s)
- Harling-McNabb, L; Deliyannis, G; Jackson, DC; Gerondakis, S; Grigoriadis, G; Brown, LE;
- Details
- Publication Year 1999-09,Volume 11,Issue #9,Page 1431-1439
- Journal Title
- INTERNATIONAL IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Rel, a haemopoietic cell-restricted member of the NF-kappa B/Rel family Of transcription factors, has recently been shown to be important in the function of a and T lymphocytes, In an attempt to understand the role of this protein in the immune response, we examined the ability of Rel(-/-) mice to counter an influenza virus infection. Normal levels of virus-specific cytotoxic T cells induced in Rel(-/-) mice were able to clear virus from the lungs, albeit with somewhat delayed kinetics compared to normal mice. Rel(-/-) mice did, however, display a markedly reduced T cell proliferative response to the virus, and exhibited impaired local and systemic influenza virus-specific antibody responses. This defect was sufficient to result in an inability of vaccinated mice, but not of previously infected mice, to acquire antibody-dependent protective immunity to reinfection with the same virus. These findings establish that during the response to influenza virus, Rel function allows optimal development of humoral immunity, a role that apparently cannot be fulfilled by other NF-kappa B/Rel proteins.
- Publisher
- OXFORD UNIV PRESS
- Keywords
- NF-KAPPA-B; C-REL; VIRUS HEMAGGLUTININ; TARGETED DISRUPTION; MULTIFOCAL DEFECTS; SYNTHETIC PEPTIDE; IMMUNE-RESPONSES; EXHIBIT DEFECTS; DEFICIENT MICE; EXPRESSION
- Publisher's Version
- https://doi.org/10.1093/intimm/11.9.1431
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-09-01 12:00:00