Chromosomes X, 9, and the H2 locus interact epistatically to control Leishmania major infection
- Author(s)
- Roberts, LJ; Baldwin, TM; Speed, TP; Handman, E; Foote, SJ;
- Details
- Publication Year 1999-09,Volume 29,Issue #9,Page 3047-3050
- Journal Title
- EUROPEAN JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- As in other infectious diseases, the outcome of a Leishmania major infection is closely tied to the T helper cell response type; progressive disease is associated with a predominant Th2 lymphocyte response, healing with a Th1 response. In mice, susceptibility is genetically controlled, with BALB/c (C) mice being susceptible and C57BL/6 (B) mice being resistant. Using a genome-wide scan on two large populations of F2 mice created from these strains, we have shown previously that susceptibility to infection with L. major is controlled by two autosomal loci: lmr1 at the H2 locus, and lmr2 on chromosome 9. Employing a strategy to identify loci that interact, we show here that lmr1 and lmr2 interact synergistically, and we describe a new locus lmr3, lying on the X chromosome, whose effect depends on a specific lmr1 haplotype.
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- RECONSTITUTED NUDE-MICE; CUTANEOUS LEISHMANIASIS; CD40 LIGAND; RESISTANCE; TROPICA; COSTIMULATION; IMMUNITY
- Publisher's Version
- https://doi.org/10.1002/(SICI)1521-4141(199909)29:09<3047::AID-IMMU3047>3.0.CO;2-L
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-09-01 12:00:00