Negative regulators of cytokine signal transduction
- Author(s)
- Hilton, DJ;
- Details
- Publication Year 1999-09,Volume 55,Issue #12,Page 1568-1577
- Journal Title
- CELLULAR AND MOLECULAR LIFE SCIENCES
- Publication Type
- Journal Article
- Abstract
- Enormous advances have been made over the last 10 years in unravelling cytokine signal transduction. This work has led to the recognition of the prime importance of Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). More recently, the importance of negative regulators of this pathway has begun to be realised. There is now evidence for at least three families of proteins that inhibit JAK/STAT signalling. The supressors of cytokine signalling (SOCS), protein inhibitors of activated STATs (PIAS) and the SH2-containing phosphatase (SHP-1). This review describes some of the key features of SOCS proteins and contrasts their actions with other negative regulators, the PIAS proteins and SHP-1.
- Publisher
- BIRKHAUSER VERLAG AG
- Keywords
- TYROSINE PHOSPHATASE SHPTP1; ERYTHROPOIETIN RECEPTOR; SH2 DOMAIN; TARGETED DISRUPTION; INTERFERON-GAMMA; STAT5 ACTIVATION; POINT MUTATION; INDUCIBLE GENE; PROTEIN; PATHWAY
- Publisher's Version
- https://doi.org/10.1007/s000180050396
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-09-01 12:00:00