Signaling of neuronal cell death by the p75NTR neurotrophin receptor
- Author(s)
- Coulson, EJ; Reid, K; Bartlett, PF;
- Details
- Publication Year 1999-08,Volume 20,Issue #1,Page 29-44
- Journal Title
- MOLECULAR NEUROBIOLOGY
- Publication Type
- Journal Article
- Abstract
- The neurotrophin receptor (p75NTR) is best known for mediating tropic support by participating in the formation of high-affinity nerve growth factor (NGF) receptor complexes with trkA, however, p75NTR more recently has been shown to act as a bona fide death-signaling receptor, which can signal independently of trkA. This article discusses the evidence for an active role of p75NTR in neuronal cell death and the mechanisms controlling this process, including roles for Bcl-2 family members, the c-jun stress kinase JNK, the transcription factor nuclear factor kappa B (NF kappa B), and caspases.
- Publisher
- HUMANA PRESS INC
- Keywords
- NERVE GROWTH-FACTOR; AFFINITY NGF RECEPTOR; NF-KAPPA-B; DORSAL-ROOT GANGLIA; X-DEFICIENT MICE; PROTEIN-KINASE; CYTOCHROME-C; TERMINAL KINASE; PC12 CELLS; CHOLINE-ACETYLTRANSFERASE
- Publisher's Version
- https://doi.org/10.1007/BF02741363
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1999-08-01 12:00:00